Development and Evaluation of Self Micro Emulsifying Drug Delivery System (SMEDDS) for Nebivolol Hydrochloride

The present investigation aimed to prepare a self micro emulsifying drug delivery system (SMEDDS) for the dissolution enhancement of nebivolol hydrochloride. main objective this work was develop, characterize, and evaluate solid SMEDDS prepared by using adsorption technique liquid improve solubility rate excipients were chosen based on high hydrochloride, their concentrations optimized constructing ternary phase diagrams. Thirty-two combinations oil (Labrafac Lipophile WL 1349), surfactant (Kolliphor RH 40), co-surfactant (Gelucire 44/14). Self-emulsification time, dilution studies, thermodynamic stability studies satisfactory. in vitro release profile showed faster compared with pure hydrochloride suspension marketed formulation. droplet size range 132.8±22.1 955.7±15.5 nm zeta potential -7.2±0.53 mV -46.4±0.32 selected formulations. Formulation N17 1349 -10%w/w, Kolliphor RH40-72%w/w, Gelucire 44/14- 18%w/w) considered as formulation 97.26 ± 1.16% 0.1 N HCl 120 minutes, particle mV. Thus, ratify that bioavailability improved further used preparation Solid (S-SMEDDS) formulations carriers. exhibited 95.38 0.76% releases, which significantly higher than solution. nebivolol-loaded S-SMEDDS complete min result confirmed use oral poorly water-soluble nebivolol.